Protective Effect of the Immunosuppressant Sirolimus Against Aortic Atherosclerosis In Apo E-Deficient Mice

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Andrew Plump, Jonathan D. Smith, Tony Hayek et al. · Cell · 1992 · 2.3K citations

Life Sciences, Genetics, Molecular Genetics +10

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

Joseph Heitman, N. Rao Movva, Michael N. Hall · Science · 1991 · 2K citations

Life Sciences, Cell Biology, Molecular Biology +17

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Yutaka Nakashima, Andrew Plump, Elaine W. Raines et al. · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · 1994 · 1.7K citations

Veterinary Medicine, Cardiology, Pathobiology +17

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

Keiko Nakayama, Keiko Nakayama, N. Ishida et al. · Cell · 1996 · 1.6K citations · Full text

Medicine, Endocrinology, Oncology +17

Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.

Lena Jonasson, Jan Holm, Omar Skalli et al. · Arteriosclerosis An Official Journal of the American Heart Association Inc · 1986 · 1.3K citations · Full text

Veterinary Medicine, Immunology, Pathology +14