Angewandte Chemie International Edition · 2011 · 56 citations · 34 references
Life SciencesChemical BiologyMolecular BiologyGene ExpressionSignal TransductionTranscriptional RegulationCis-regulatory ElementsCore Promoter ElementsLigand BindingProtein-ligand BindingSignal Transduction ComplexesTranscription In EukaryotesBlockingDna Binding SitesNuclear Receptor Coactivator ComplexesPlatinum CompoundsPromoter Activation MotifsTranscription Factor Binding SitesTranscription Factor ComplexesTranscriptional Repressor Complexes
In the groove: The unique major-groove-binding properties of a PtII complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the PtII center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Wei Lu, Baoxiu Mi, Michael C. W. Chan et al. · Journal of the American Chemical Society · 2004 · 613 citations