Concepedia

Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2

Karl Vollmann, Ramatullah Qurishi, Jörg Hockemeyer, Christa E. Müller

Molecules · 2008 · 45 citations · 17 references

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Concepts

Abstract

The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A2A receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleaved by pig liver esterase.

References

17

Valacyclovir: A Substrate for the Intestinal and Renal Peptide Transporters PEPT1 and PEPT2

Malliga E. Ganapathy, Wei Huang, Hong Wang et al. · Biochemical and Biophysical Research Communications · 1998 · 295 citations · Full text

, , +10

Amino Acid Ester Prodrugs of Acyclovir

Lilia M. Beauchamp, G. Faye Orr, P de Miranda et al. · Antiviral chemistry & chemotherapy · 1992 · 214 citations · Full text

, , +17

Opposite modulatory roles for adenosine A<sub>1</sub>and A<sub>2A</sub>receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure

Davide Quarta, Sergi Ferré, Marcello Solinas et al. · Journal of Neurochemistry · 2004 · 164 citations

, , +17

Adenosine A<sub>2A</sub> receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

Liqun Yu, Hai‐Ying Shen, Joana E. Coelho et al. · Annals of Neurology · 2008 · 158 citations · Full text

, , +17

Multigram-Scale Syntheses, Stability, and Photoreactions of A<sub>2A</sub> Adenosine Receptor Antagonists with 8-Styrylxanthine Structure:  Potential Drugs for Parkinson's Disease

Jörg Hockemeyer, Joachim C. Burbiel, Christa E. Müller · The Journal of Organic Chemistry · 2004 · 138 citations

, , +10