Effect of a sulfated polysaccharide on peptic digestion. A study in vitro of carrageenin (Ebimar).

Abstract

Summary 1.The two sulfated polysaccharides, Ebimar and heparin, inhibit peptic digestion. 2.Ebimar appears to act predominantly on substrate in digestion studies. It is less active at high substrate levels but is uninfluenced by the pepsin concentration. 3.Ebimar alters the electrophoresic mobility of albumin at pH 2 and 4, but has little effect on pepsin at these pH levels. 4.Previous work on the mode of action of the sulfated polysaccharides on proteins is discussed in relation to the above findings with Ebimar.