Simple Palladium(II) Precatalyst for Suzuki−Miyaura Couplings:  Efficient Reactions of Benzylic, Aryl, Heteroaryl, and Vinyl Coupling Partners

Abstract

trans-PdBr(N-Succ)(PPh3)2 (1) is a universally effective precatalyst for Suzuki-Miyaura cross-couplings of benzylic halides with aryl- or heteroarylboronic acids. Substituted aryl halides and halogenated cyclic enones can be cross-coupled with aryl- or vinylboronic acids in excellent yields. Catalyst recycling is also demonstrated.