ANTIEMETICS: NEUROTRANSMITTER RECEPTOR BINDING PREDICTS THERAPEUTIC ACTIONS

Antiemetic Efficacy of High-Dose Metoclopramide: Randomized Trials with Placebo and Prochlorperazine in Patients with Chemotherapy-Induced Nausea and Vomiting

Richard J. Gralla, Loretta M. Itri, Sharon E. Pisko et al. · New England Journal of Medicine · 1981 · 710 citations

Medicine, Pharmacology, Pharmacotherapy +17

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

Stephen J. Peroutka · American Journal of Psychiatry · 1980 · 544 citations

Medicine, Pharmacology, Psychiatry +17

Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem

JK Wamsley, MS Lewis, W. Scott Young et al. · Journal of Neuroscience · 1981 · 377 citations · Full text

Medicine, Neurobiology, Neuroscience +13

The distribution of histamine H1-receptors in the rat brain: An autoradiographic study

José Palacios, James K. Wamsley, M. J. Kuhar · Neuroscience · 1981 · 290 citations

Life Sciences, Neurobiology, Neuroscience +7

Incidence of nausea and vomiting with cytotoxic chemotherapy: a prospective randomised trial of antiemetics.

C G Morran, Dawn Smith, Douglas Anderson et al. · BMJ · 1979 · 135 citations · Full text

Medicine, Oncology, Pharmacotherapy +14