Gold(I)‐Catalyzed 5‐<i>endo</i> Hydroxy‐ and Alkoxycyclization of 1,5‐Enynes: Efficient Access to Functionalized Cyclopentenes

Abstract

The rapid and stereoselective construction of highly functionalized cyclopentenes is possible through gold(I)-catalyzed 5-endo hydroxy- and methoxycyclizations of 1,5-enynes. More complex 5,7- and 5,8-fused bicyclic structures of a type found in many terpene natural products can be formed by combining the cyclization reaction with ring-closing metathesis (RCM; see scheme).