Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blind, randomised trial

“Proving the null hypothesis” in clinical trials

William C. Blackwelder · Controlled Clinical Trials · 1982 · 899 citations

Natural Sciences, Biostatistics, Experimental Design +10

Two Controlled Trials of Antibiotic Treatment in Patients with Persistent Symptoms and a History of Lyme Disease

Mark S. Klempner, Linden T. Hu, Janine Evans et al. · New England Journal of Medicine · 2001 · 775 citations · Full text

Pharmacy, Infectious Diseases, Pharmacotherapy +16

Study and treatment of post Lyme disease (STOP-LD)

Lauren Krupp, Leslie Hyman, Roger Grimson et al. · Neurology · 2003 · 425 citations

Veterinary Medicine, Infectious Diseases, Internal Medicine +11

A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy

Brian A. Fallon, John G. Keilp, Kathy Corbera et al. · Neurology · 2007 · 396 citations · Full text

Medicine, Neurology, Pharmacotherapy +14

Practice Parameter: Treatment of nervous system Lyme disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology [RETIRED]

John Halperin, Eugene D. Shapiro, Eric L. Logigian et al. · Neurology · 2007 · 323 citations · Full text

Pharmacy, Neurology, Pharmacotherapy +17