“Proving the null hypothesis” in clinical trials

IX. On the problem of the most efficient tests of statistical hypotheses

Jerzy Neyman, Egon S. Pearson · Philosophical Transactions of the Royal Society of London Series A Containing Papers of a Mathematical or Physical Character · 1933 · 2.3K citations · Full text

Natural Sciences, Mathematics, Causal Inference +11

The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial

Jennie A. Freiman, Thomas C. Chalmers, Harry Smith et al. · New England Journal of Medicine · 1978 · 1.6K citations

Public Health, Biostatistics, Experimental Design +16

One-Sample Multiple Testing Procedure for Phase II Clinical Trials

Thomas R. Fleming · Biometrics · 1982 · 997 citations

Medicine, Oncology, Clinical Trial Regulation +13

Testing Statistical Hypotheses.

N. L. J., E. H. Lehmann · The Incorporated Statistician · 1960 · 917 citations

A Comparison of Amphotericin B Alone and Combined with Flucytosine in the Treatment of Cryptoccal Meningitis

John E. Bennett, William E. Dismukes, Richard J. Duma et al. · New England Journal of Medicine · 1979 · 871 citations

Pharmacy, Infectious Diseases, Pharmacology +12