A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice - Concepedia

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Publication | Open Access

A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice

DOI Full Paper Access

56

Citations

46

References

2007

Year

Wessel P. Dirksen, Véronique A. Lacombe, Miaofang Chi, Anuradha Kalyanasundaram, Serge Viatchenko‐Karpinski, Dmitry Terentyev, Zhifeng Zhou, Srikanth Vedamoorthyrao, Na Li, Nipavan Chiamvimonvat

Cardiovascular Research

Abstract

The findings of the present study demonstrate that expression of mutant CASQ2(D307H) in the mouse heart results in abnormal myocyte Ca2+ handling and predisposes to complex ventricular arrhythmias similar to the CPVT phenotype observed in human patients.

References

	Year	Citations

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