The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H ⁺ -ATPase Assembly in Murine Cardiomyocytes

Abstract

Genetic ablation of Atp6ap2 created a loss-of-function model for V-ATPase. The gene product of ATP6AP2 is considered to act as in 2 ways: (1) as (P)RR, exerting a RAS-related function; and (2) as the V-ATPase-associated protein, exerting a non-RAS-related function that is essential for cell survival.