Concepedia

Publication | Open Access

Aldosterone Induces Angiotensin-Converting-Enzyme Gene Expression in Cultured Neonatal Rat Cardiocytes

DOIFull Paper Access

212

Citations

17

References

2001

Year

Eisaku Harada, Michihiro Yoshimura, Hirofumi Yasue, Osamu Nakagawa, Masayo Nakagawa, Masaki Harada, Yuji Mizuno, Masafumi Nakayama, Yukio Shimasaki, Teruhiko Ito,
Circulation

Abstract

Aldosterone upregulates ACE mRNA expression, which is blocked by spironolactone in neonatal rat cardiocytes. Thus, spironolactone may suppress the progression of heart failure by blocking the effects of aldosterone and angiotensin II.

References

YearCitations

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