Baicalein Induces Functional Hypoxia-Inducible Factor-1α and Angiogenesis

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Redox Signaling, Molecular Physiology, Mammalian Homologs Define +11

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

Richard K. Bruick, Steven L. McKnight · Science · 2001 · 2.5K citations

Chemical Biology, Redox Biology, Oxidative Stress +16

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

David Lando, Daniel J. Peet, Jeffrey J. Gorman et al. · Genes & Development · 2002 · 1.5K citations · Full text

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1  in normoxia

Edurne Berra · The EMBO Journal · 2003 · 1.3K citations · Full text

Hif Prolyl-hydroxylase 2, Key Oxygen Sensor, Biochemistry +9