Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Expression of a multidrug-resistance gene in human tumors and tissues.

Antonio Tito Fojo, Kazumitsu Ueda, Dennis J. Slamon et al. · Proceedings of the National Academy of Sciences · 1987 · 1.6K citations · Full text

Medicine, Oncology, Pharmacology +11

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

Carlos Cordon‐Cardo, James P. O’Brien, João Paulo Boccia et al. · Journal of Histochemistry & Cytochemistry · 1990 · 1.1K citations

Medicine, Molecular Biology, Oncology +14

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

Norbert Kartner, John R. Riordan, Victor Ling · Science · 1983 · 1K citations

Medicine, Oncology, Pharmacology +15

P-Glycoprotein, a gatekeeper in the blood–brain barrier

Alfred H. Schinkel · Advanced Drug Delivery Reviews · 1999 · 954 citations

Medicine, Neuroscience, Pharmacology +8