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Dynamic kinetic resolution: an efficient route to anti α-amino-β-hydroxy esters via Ru-SYNPHOS<sup>®</sup>catalyzed hydrogenation

Céline Mordant, Pascal Dünkelmann, Virginie Ratovelomanana‐Vidal, Jean‐Pierre Genêt

Chemical Communications · 2004 · 61 citations · 20 references

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Abstract

The Ru(II)-catalyzed hydrogenation of α-amino-β-keto esters as their hydrochloride salts affords preparation of the corresponding anti α-amino-β-hydroxy esters under mild conditions with high diastereoselectivities and enantioselectivities via dynamic kinetic resolution.

References

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