Choline‐Derivate‐Modified Nanoparticles for Brain‐Targeting Gene Delivery

Abstract

The choline transporter (ChT) is used to transporte choline-derivate-modified nanoparticles across the blood-brain barrier. It is demonstrated that ChT is an ideal Trojan horse. The choline-derivate-modified nanoparticles exhibit higher permeability across the brain capillary endothelial cells (BCECs) monolayer in vitro and higher gene distribution and expression in vivo. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.