A Case Of Convergence: Why Did a Simple Alternative to Canonical Antibodies Arise in Sharks and Camels?

Naturally occurring antibodies devoid of light chains

C. Hamers‐Casterman, T. Atarhouch, Serge Muyldermans et al. · Nature · 1993 · 3.2K citations

Pharmacy, Biochemistry, Immunology +14

A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks

Andrew S. Greenberg, David Ávila, Marianne K. Hughes et al. · Nature · 1995 · 757 citations

Life Sciences, Genetics, Molecular Biology +16

Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies

Erwin De Genst, Karen Silence, Klaas Decanniere et al. · Proceedings of the National Academy of Sciences · 2006 · 666 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Camelid immunoglobulins and nanobody technology

Serge Muyldermans, Toya Nath Baral, V. Cortez Retamozzo et al. · Veterinary Immunology and Immunopathology · 2008 · 539 citations · Full text

Life Sciences, Biotechnology, Immunology +14

Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme

Aline Desmyter, Thomas R. Transue, Mehdi Arbabi Ghahroudi et al. · Nature Structural & Molecular Biology · 1996 · 513 citations

Life Sciences, Biochemistry, Molecular Biology +14