THE DISTRIBUTION AND EXCRETION OF S35-LABELED SULFO-BROMOPHTHALEIN-SODIUM ADMINISTERED TO DOGS BY CONTINUOUS INFUSION 1

Abstract

It has been known for some time that continuous tent, upon assumptions regarding the storage of intravenous infusion of sulfo-bromophthalein-so-the dye in tissues supplied by the splanchnic ir- dium (referred to below as BSP) in dogs as well culation; second, BSP is a most useful prototype as in man results eventually in a steady state in substance for theoretical studies of bile formation which blood and bile concentrations, and usually and bile secretion, and knowledge of its actual the rate of biliary excretion of the dye, remain sites of deposition is essential if serious errors of constant (1). Bradley and co-workers have interpretation are to be avoided in this connection. pointed out that such a steady state can only be