Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation

Abstract

Compounds <bold>14</bold> and <bold>62</bold> were identified using virtual screening to inhibit autophagy. The expression levels of the LC3-II and p62 autophagy proteins were used. SAR analysis revealed another active compound <bold>38</bold>. Formation of autophagosomes was severely reduced upon dosing of <bold>14</bold>, <bold>38</bold> and <bold>62.</bold>