Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 181.5K citations

Life Sciences, Molecular Biology, Molecular Genetics +9

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Christopher J. Sinal, Masahiro Tohkin, Masaaki Miyata et al. · Cell · 2000 · 1.8K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +12

Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase

Colin J. Henderson, Diana M. E. Otto, Mark A. Magnuson et al. · Journal of Biological Chemistry · 2003 · 260 citations · Full text

Medicine, Biochemistry, Pharmacology +10

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

Russell A. DeBose‐Boyd, Jiafu Ou, Joseph L. Goldstein et al. · Proceedings of the National Academy of Sciences · 2001 · 248 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Association of Multiple Developmental Defects and Embryonic Lethality with Loss of Microsomal NADPH-Cytochrome P450 Oxidoreductase

Anna L. Shen, Kathleen A. O’Leary, Charles B. Kasper · Journal of Biological Chemistry · 2002 · 233 citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16