Compartmental Modeling of¹¹C-HOMADAM Binding to the Serotonin Transporter in the Healthy Human Brain

Abstract

(11)C-HOMADAM is a highly promising radioligand with high ratios of specific binding to nonspecific binding in known SERT-rich structures, such as the raphe nuclei. The 3-parameter reference tissue model approach permits a simplified quantitatively accurate method for estimating SERT binding potentials.