Ribosomal Synthesis of Backbone‐Macrocyclic Peptides Containing γ‐Amino Acids

Abstract

Mine's in the middle: We report here a novel methodology for the ribosomal synthesis of backbone-macrocyclic peptides containing γ-amino acids under the reprogrammed genetic code. Integration of reprogrammed initiation by using exotic dipeptides with C-terminal diketopiperadine-thioester formation has successfully afforded backbone-cyclized peptides with γ-amino acids at an internal position.