Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension

Abstract

Our data demonstrate that A-17 improves heart and lung function in experimental PH by interfering with lung vascular and right ventricular remodeling. The beneficial effects may be related to the up-regulation of p21. Thus, inhibition of miR-17 may represent a novel therapeutic concept to ameliorate disease state in PH.