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A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential CH Functionalization

Andrew K. Pitts, Fionn O’Hara, Robert H. Snell, Matthew J. Gaunt

Angewandte Chemie International Edition · 2015 · 121 citations · 46 references

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Abstract

A sequential CH functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product.

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