Nano Letters · 2008 · 269 citations · 25 references
EngineeringBiomedical EngineeringOncologyBiomedical OpticsNanomaterialsNanotechnologyCancer NanomedicineCarbon NanotubesNanomedicineNanotubesRaman SpectroscopyTumor ImagingControl Group DesignMatched Control GroupRaman ImagingRaman MicroscopyRaman SpectraRaman Spectroscopy Of NanotubesSingle-walled Carbon Nanotubes
An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
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In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
Weibo Cai, Nozomi Nakayama, Xiaoming Sun et al. · Nature Nanotechnology · 2006 · 1.4K citations