New aryloxy-quinone derivatives as potential anti-Chagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis

Abstract

A set of new aryloxy-quinones were synthesized and evaluated<italic>in vitro</italic>against the epimastigote form of<italic>Trypanosoma cruzi</italic>and their unspecific cytotoxicity was tested on murine macrophages J-774 cells.