Concepedia

Pharmacophore Optimization

Pharmacophore Optimization is the systematic refinement of a pharmacophore—the essential spatial and chemical features responsible for a molecule's biological activity—to enhance its potency, selectivity, or drug-like properties through iterative structural modifications and structure-activity relationship analysis.

184

Publications

8.2K

Citations

1.1K

Authors

345

Institutions

Publications per year

2017–2026

42

Parents

Publications

184

“Scaffold-Hopping” by Topological Pharmacophore Search: A Contribution to Virtual Screening

Gisbert Schneider, Werner Neidhart, Thomas Giller et al. · Angewandte Chemie International Edition · 1999 · 691 citations

, , +14

A genetic algorithm for flexible molecular overlay and pharmacophore elucidation

Gareth Jones, Peter Willett, Robert C. Glen · Journal of Computer-Aided Molecular Design · 1995 · 392 citations

, , +16

Coumarin-Based Inhibitors of HIV Integrase

He Zhao, Nouri Neamati, Huixiao Hong et al. · Journal of Medicinal Chemistry · 1997 · 274 citations · Full text

, , +17

Discovery of Novel <i>p</i>-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead

Gang Liu, J. T. Link, Zhonghua Pei et al. · Journal of Medicinal Chemistry · 2000 · 218 citations · Full text

, , +17

Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

Sean Ekins, Richard B. Kim, Brenda F. Leake et al. · Molecular Pharmacology · 2002 · 166 citations · Full text

, , +17

1–5 of 184

Authors

1.1K

  1. LH
    Laleh Hoghooghi Rad

    Research Institute for Endocrine Sciences, Iran

    3 publications · 50 citations

    3

    h-index

  2. ES
    Emin Sarıpınar

    Erciyes University, Türkiye

    3 publications · 65 citations

    3

    h-index

  3. MF
    Mehrdad Faizi

    Shahid Beheshti University of Medical Sciences, Iran

    3 publications · 50 citations

    3

    h-index

  4. QY
    Qidong You

    China Pharmaceutical University, China

    3 publications · 55 citations

    3

    h-index

  5. EY
    Ersin Yanmaz

    Erciyes University, Türkiye

    3 publications · 65 citations

    3

    h-index

1–5 of 1.1K

Institutions

345

  1. National Institutes of Health

    Bethesda, United States

    5 h-index

    32 publications

    3.4K citations

  2. Shahid Beheshti University of Medical Sciences

    Tehran, Iran

    4 h-index

    14 publications

    221 citations

  3. China Pharmaceutical University

    Nanjing, China

    4 h-index

    13 publications

    255 citations

  4. Erciyes University

    Kayseri, Türkiye

    4 h-index

    10 publications

    179 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    26 publications

    754 citations

  6. China Medical University

    Taichung, Taiwan

    3 h-index

    12 publications

    630 citations

  7. Universidade de São Paulo

    São Paulo, Brazil

    3 h-index

    8 publications

    156 citations

  8. National Tsing Hua University

    Hsinchu, Taiwan

    3 h-index

    4 publications

    360 citations

1–8 of 345

Venues

  1. Journal of Medicinal Chemistry

    30 publications · 2.2K citations

    24

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    18 publications · 592 citations

    15

    h-index

  3. Bioorganic & Medicinal Chemistry

    9 publications · 213 citations

    9

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 8 publications · 373 citations

    8

    h-index

  5. Journal of Computer-Aided Molecular Design

    7 publications · 573 citations

    7

    h-index

1–5