Effect of CYP3A5, CYP3A4, and ABCB1 Genotypes as Determinants of Tacrolimus Dose and Clinical Outcomes After Heart Transplantation

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

Optimization of Initial Tacrolimus Dose Using Pharmacogenetic Testing

Éric Thervet, Marie‐Anne Loriot, S. Barbier et al. · Clinical Pharmacology & Therapeutics · 2010 · 363 citations

Medicine, Pharmacokinetics, Pharmacology +17

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and p-glycoprotein correlate with dose requirement

Iain MacPhee, Salim Fredericks, Tracy W Tai et al. · Transplantation · 2002 · 314 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Impact of cytochrome P450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients1 2

Éric Thervet, Dany Anglicheau, Barry P. King et al. · Transplantation · 2003 · 300 citations

Medicine, Pharmacokinetics, Pharmacology +17

EFFECT OF CYP3A5 POLYMORPHISM ON TACROLIMUS METABOLIC CLEARANCE IN VITRO

Yang Dai, Mary F. Hébert, Nina Isoherranen et al. · Drug Metabolism and Disposition · 2006 · 276 citations

Medicine, Pharmacokinetics, Pharmacology +17