Novel Synthetic Approach Toward (±)-β-Cuparenone via Palladium-Catalyzed Tandem Heck Cyclization of 1-Bromo-5-methyl-1-aryl-hexa-1,5-dien-3-ol Derivatives

Abstract

A novel and convenient synthetic route toward (+/-)-beta-cuparenone and many other sesquiterpene natural product precursors has been developed via palladium-catalyzed tandem Heck cyclization of 1-bromo-5-methyl-1-aryl-hexa-1,5-dien-3-ols. [reaction: see text].