Chemokine Receptor<i>CXCR4</i>Expression in Colorectal Cancer Patients Increases the Risk for Recurrence and for Poor Survival

Abstract

CXCR4, a well-characterized chemokine receptor for T-cells, is differentially expressed in CRC. CXCR4 gene expression in primary CRC demonstrated significant associations with recurrence, survival, and liver metastasis. The CXCR4-CXCL12 signaling mechanism may be clinically relevant for patients with CRC and represents a potential novel target for disease-directed therapy.