Conformationally Rigid Trifluoromethyl‐Substituted α‐Amino Acid Designed for Peptide Structure Analysis by Solid‐State ¹⁹F NMR Spectroscopy

Abstract

Designing a sturdy label: The fluorinated amino acid l-CF3-Bpg (see picture), which was specifically designed as a 19F NMR label for structure analysis of membrane-bound peptides, does not display the drawbacks of previously used labels. The amino acid can be readily incorporated into peptides and is particularly suitable as a substitute for Leu, Ile, and Met.