Proceedings of the National Academy of Sciences · 1978 · 363 citations · 3 references
Life SciencesBiologyMolecular BiologyChromatin StructureMolecular BiophysicsStructural BiologyDna StructureNucleosome StructureDna Wrapping Around NucleosomesDna Wrapping Around The NucleosomeLinking
A closed duplex DNA molecule relaxed and containing nucleosomes has a different linking number from the same molecule relaxed and without nucleosomes. What does this say about the structure of the nucleosome? A mathematical study of this question is made, representing the DNA molecule by a ribbon. It is shown that the linking number of a closed ribbon can be decomposed into the linking number of a reference ribbon plus a sum of locally determined "linking differences."
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Linking numbers and nucleosomes.
F H Crick · Proceedings of the National Academy of Sciences · 1976 · 291 citations · Full text