Biosynthesis of the polyketide antibiotic ICI139603 in Streptomyces longisporoflavus: assignment of the 13C n.m.r. spectrum by two-dimensional methods, and determination of the origin of the carbon atoms

J.Mark Bulsing, Ernest D. Laue, Finian J. Leeper, James Staunton, D. Huw Davies, Graham A. F. Ritchie, Alan B. Davies, Alan B. Davies, Richard P. Mabelis

Journal of the Chemical Society Chemical Communications · 1984 · 22 citations · 0 references

Concepts

Abstract

The carbon skeleton of the polyether antibiotic ICI139603 (1) is shown to consist of a polyketide chain, derived from seven acetate units and six propionate units, combined with a C2-unit of unknown origin.