Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation

Neurobiology of substance P and the NK1 receptor.

Patrick W. Mantyh · PubMed · 2002 · 287 citations

Life Sciences, Neurobiology, Neuroscience +17

CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.

C Pothoulakis, Ignazio Castagliuolo, J. Thomas LaMont et al. · Proceedings of the National Academy of Sciences · 1994 · 277 citations

Life Sciences, Immunology, Pharmacology +17

Substance P induces TNF-α and IL-6 production through NFκB in peritoneal mast cells

Antonina Azzolina, Antonella Bongiovanni, Nadia Lampiasi · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2003 · 198 citations

Life Sciences, Cell Biology, Immunology +13

The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells

Klaus Lieb, Bernd L. Fiebich, Michael F. Berger et al. · The Journal of Immunology · 1997 · 193 citations

Life Sciences, Neurobiology, Neuroscience +17

NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats

Arthur F. Stucchi, Scott Shofer, Susan E. Leeman et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2000 · 177 citations · Full text

Medicine, Immunology, Pharmacology +17