Dynamic Combinatorial Resolution: Direct Asymmetric Lipase‐Mediated Screening of a Dynamic Nitroaldol Library

Abstract

A disturbance in the library: The nitroaldol (Henry) reaction was developed as an efficient CC bond-forming route to dynamic combinatorial libraries (DCLs). These DCLs generated under thermodynamic control were coupled in a one-pot process with kinetically controlled lipase-mediated transesterification (see scheme). The asymmetric resolution of the DCLs by the enzyme led to enantiomerically pure β-nitroacetates in high yield.