Dynamic Combinatorial Resolution: Direct Asymmetric Lipase‐Mediated Screening of a Dynamic Nitroaldol Library

Abstract

A disturbance in the library: The nitroaldol (Henry) reaction was developed as an efficient CC bond-forming route to dynamic combinatorial libraries (DCLs). These DCLs generated under thermodynamic control were coupled in a one-pot process with kinetically controlled lipase-mediated transesterification (see scheme). The asymmetric resolution of the DCLs by the enzyme led to enantiomerically pure β-nitroacetates in high yield. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603740_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.