Concepedia

Dynamic kinetic resolution of 2-oxo-3-aryl-succinates by organocatalyzed aldolization

Yajun Wang, Zongxuan Shen, Bin Li, Yong Zhang

Chemical Communications · 2007 · 40 citations · 19 references

DOI

Concepts

Abstract

The dynamic kinetic resolution of 2-oxo-3-arylsuccinates was achieved vial-proline-catalyzed addition of acetone in acetonitrile at room temperature, providing the desired adduct in good yield with up to 87 : 13 dr and high ee up to 99%.

References

19

Proline-Catalyzed Direct Asymmetric Aldol Reactions

Benjamin List, Richard A. Lerner, Carlos F. Barbas · Journal of the American Chemical Society · 2000 · 2.8K citations

, , +10

Amino Acid Catalyzed Direct Asymmetric Aldol Reactions:  A Bioorganic Approach to Catalytic Asymmetric Carbon−Carbon Bond-Forming Reactions

Kandasamy Sakthivel, Wolfgang Notz, Tommy Bui et al. · Journal of the American Chemical Society · 2001 · 1.2K citations

, , +13

Catalytic Asymmetric Synthesis of <i>anti-</i>1,2-Diols

Wolfgang Notz, Benjamin List · Journal of the American Chemical Society · 2000 · 642 citations

, , +12

Quantum Mechanical Predictions of the Stereoselectivities of Proline-Catalyzed Asymmetric Intermolecular Aldol Reactions

Sogole Bahmanyar, K. N. Houk, Harry J. Martin et al. · Journal of the American Chemical Society · 2003 · 577 citations

, , +13

Dynamic kinetic resolution

Hélène Pellissier · Tetrahedron · 2003 · 561 citations