IEEE/ACM Transactions on Computational Biology and Bioinformatics · 2006 · 212 citations · 19 references
ComputingBiologyAlgorithmsGenome OrganizationGenomic Data AnalysisGenome RearrangementSorting AlgorithmsBest ApproximationPermutationsSimple PermutationsUpper Bound Computation
Sorting permutations by transpositions is an important problem in genome rearrangements. A transposition is a rearrangement operation in which a segment is cut out of the permutation and pasted in a different location. The complexity of this problem is still open and it has been a 10-year-old open problem to improve the best known 1.5-approximation algorithm. In this paper, we provide a 1.375-approximation algorithm for sorting by transpositions. The algorithm is based on a new upper bound on the diameter of 3-permutations. In addition, we present some new results regarding the transposition diameter: we improve the lower bound for the transposition diameter of the symmetric group and determine the exact transposition diameter of simple permutations.
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Transforming cabbage into turnip
Sridhar Hannenhalli, Pavel A. Pevzner · Journal of the ACM · 1999 · 652 citations · Full text
Life Sciences, Biology, Genetics +13
Vineet Bafna, Pavel A. Pevzner · SIAM Journal on Discrete Mathematics · 1998 · 416 citations
Genome Rearrangements and Sorting by Reversals
Vineet Bafna, Pavel A. Pevzner · SIAM Journal on Computing · 1996 · 406 citations
Life Sciences, Biology, Genetics +12