Intratumoral Heterogeneity of <i>ALK</i>-Rearranged and <i>ALK</i>/<i>EGFR</i> Coaltered Lung Adenocarcinoma

Abstract

Intratumoral genetic heterogeneity was demonstrated to coexist with histologic heterogeneity in both single-driver and ALK/EGFR coaltered LADCs. Altered oncogenic drivers in spatially separated subclones of the same tumor may be different.