Use of a Perfluoroalkylsulfonyl (PFS) Linker in a “Traceless” Synthesis of Biaryls through Suzuki Cleavage

Abstract

Three roles for the PFS fluoride resin 1: a linker, a protecting group, and an activating group for phenols. Immobilized “aryl triflates” 2 are generated upon treatment of 1 with phenols. Through a subsequent Suzuki cleavage/cross-coupling reaction an additional aryl group can be appended to the initial phenol to afford biaryls 3 in a “traceless” fashion in high yields.