Transport of Rhodamine 123, a P-Glycoprotein Substrate, across Rat Intestine and Caco-2 Cell Monolayers in the Presence of Cytochrome P-450 3A-Related Compounds

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth

Shiyin Yee · Pharmaceutical Research · 1997 · 1K citations

Pharmacy, Cell Biology, Physiology +13

Route of Passive Ion Permeation in Epithelia

E. Frömter, Jared M. Diamond · Nature New Biology · 1972 · 769 citations

Natural Sciences, Biophysics, Physiology +12

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

T D Porter, Minor J. Coon · Journal of Biological Chemistry · 1991 · 679 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

Pharmacy, Pharmacokinetics, Pharmacology +17