Rapid Selection of Oseltamivir‐ and Peramivir‐Resistant Pandemic H1N1 Virus during Therapy in 2 Immunocompromised Hosts

Matthew J. Memoli, Rachel J. Hrabal, Arash Hassantoufighi, Maryna C. Eichelberger, Jeffery K. Taubenberger

Clinical Infectious Diseases · 2010 · 152 citations · 13 references

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Abstract

Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir.

References

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