A Cascade Cycloaddition Strategy Leading to the Total Synthesis of (−)-FR182877

Abstract

A tandem transannular [4+2] cycloaddition strategy is presented for the synthesis of the class of natural products containing FR182877 (1) and hexacyclinic acid (2). As part of this program, a tandem transannular [4+2] cycloaddition reaction has been employed in the enantioselective synthesis of (−)-FR182877 (1) via the macrocyclic precursor (3).