Design, Synthesis, and Membrane‐Translocation Studies of Inositol‐Based Transporters

Abstract

Delivery vehicles: Novel guanidine-containing “transporters” constructed on a dimeric inositol scaffold show significant translocation across the cell membrane and the blood–brain barrier, as well as unique in vitro and in vivo distributions. Doxorubicin was efficiently delivered to mouse-brain tissue by conjugating the compound with such a transporter (see the fluorescence microscopy image). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600312_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.