Concepedia

A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein bindingElectronic supplementary information (ESI) available: pH dependence of europium emission spectra, stability screening details and relaxivity/pH plots for selected Gd complexes. See http://www.rsc.org/suppdata/cc/b1/b108294a/

Dimitri Messeri, Mark P. Lowe, David Parker, Mauro Botta

Chemical Communications · 2001 · 57 citations · 8 references

DOIFull text

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Concepts

Abstract

The high relaxivity of [GdaDO3A]3− (r1p = 12.3 mM−1 s−1, 20 MHz, 298 K, τm = 30 ns) in water is maintained in serum solution because the binding of protein and endogeneous anions, e.g. HCO3−/CO32− is suppressed by electrostatic repulsion.

References

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