Hypermethylation of the promoter region of the E-cadherin gene (<i>CDH1</i>) in sporadic and ulcerative colitis associated colorectal cancer

Abstract

We have demonstrated hypermethylation of the promoter region in CDH1 in 46% of colorectal cancers studied. There was no difference between the UCACRC and SCRC groups. Just as there are specific differences in the genetic changes between UCACRC and SCRC, there is also likely to be a large degree of overlap among the genetic pathways of these cancers.