Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Susan P.C. Cole, Gabu Bhardwaj, James H. Gerlach et al. · Science · 1992 · 3K citations

Gene Amplification, Tumor Microenvironment, Oncogenic Agent +15

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

Takashi Tsuruo, Harumi Iida, Shigeru Tsukagoshi et al. · PubMed · 1981 · 1.5K citations

Chemoprevention Strategy, Vincristine Resistance, Medicine +11

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

Kazumitsu Ueda, Carol Cardarelli, Michael M. Gottesman et al. · Proceedings of the National Academy of Sciences · 1987 · 1.1K citations · Full text

Full-length Cdna, Immunology, Molecular Biology +16

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

Inka Leier, Gabriele Jedlitschky, Ulrike Buchholz et al. · Journal of Biological Chemistry · 1994 · 855 citations · Full text

Proteinlipid Interaction, Atp-dependent Ltc4 Transport, Molecular Biology +18

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

Susan P.C. Cole, Kathryn E. Sparks, Karen Fraser et al. · PubMed · 1994 · 773 citations

Pharmacological Characterization, Cellular Pharmacology, Drug Resistance Patterns +18