Synthesis of Macroheterocycles through Intramolecular Oxidative Coupling of Furanoid β‐Ketoesters

Abstract

It's all in the CAN: Cerium ammonium nitrate (CAN) promotes the oxidative radical cyclization of furan β-ketoesters to form macrocycles of varying ring sizes. The reaction is tolerant of unsaturation, oxygenation, and nitrogen and oxygen heterocycles in the carbon backbone tether.