Concepedia

Synthesis of Macroheterocycles through Intramolecular Oxidative Coupling of Furanoid β‐Ketoesters

K. C. Nicolaou, Christopher R. H. Hale, Christian Ebner, Christian Nilewski, Christopher F. Ahles, Derek Rhoades

Angewandte Chemie International Edition · 2012 · 33 citations · 17 references

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Concepts

Abstract

It's all in the CAN: Cerium ammonium nitrate (CAN) promotes the oxidative radical cyclization of furan β-ketoesters to form macrocycles of varying ring sizes. The reaction is tolerant of unsaturation, oxygenation, and nitrogen and oxygen heterocycles in the carbon backbone tether.

References

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, , +9

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, , +8

An Expedient Synthesis of a Functionalized Core Structure of Bielschowskysin

K. C. Nicolaou, Vikrant A. Adsool, Christopher R. H. Hale · Angewandte Chemie International Edition · 2011 · 46 citations · Full text

, , +7