Inhibition of Human Two-Pore Domain K+ Channel TREK1 by Local Anesthetic Lidocaine: Negative Cooperativity and Half-of-Sites Saturation Kinetics

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

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A simplified system for generating recombinant adenoviruses

Tong‐Chuan He, Shibin Zhou, Luís Teixeira da Costa et al. · Proceedings of the National Academy of Sciences · 1998 · 3.2K citations

Life Sciences, Biotechnology, Molecular Biology +15

Molecular Determinants of State-Dependent Block of Na ⁺ Channels by Local Anesthetics

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Science · 1994 · 861 citations

Medicine, Neuroscience, Pharmacology +17

Inhalational anesthetics activate two-pore-domain background K+ channels

Amanda Patel, Éric Honoré, Florian Lesage et al. · Nature Neuroscience · 1999 · 644 citations

Medicine, Anesthesiology, Pharmacology +12

TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.

Florian Lesage, Eric Guillemare, Michel Fink et al. · The EMBO Journal · 1996 · 549 citations · Full text

Natural Sciences, Biophysics, Physiology +16