Selective inhibitors of nuclear export (SINE) in hematological malignancies

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

Maarten Fornerod, Mutsuhito Ohno, Minoru Yoshida et al. · Cell · 1997 · 2.1K citations · Full text

Signal Transduction, Export Receptor, Signaling Pathway +10

Structural basis for leucine-rich nuclear export signal recognition by CRM1

Xiuhua Dong, Anindita Biswas, Katherine E. Süel et al. · Nature · 2009 · 319 citations

Biochemistry, Structural Bioinformatics, Natural Sciences +7

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

Y-T Tai, Yosef Landesman, Chirag Acharya et al. · Leukemia · 2013 · 299 citations · Full text

Tumor Biology, Oncology, Bone Morphogenic Protein +10

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Rosa Lapalombella, Qingxiang Sun, Katie Williams et al. · Blood · 2012 · 293 citations · Full text

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery.

Yasuhisa Adachi, Mitsuhiro Yanagida · The Journal of Cell Biology · 1989 · 248 citations · Full text

Genetics, Molecular Biology, Escherichia Coli +20