Concepedia

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway

Antonio Cittadini, M. Monti, Guido Iaccarino, Maria Carmina Castiello, Alfonso Baldi, Eduardo Bossone, Salvatore Longobardi, Alberto M. Marra, Valentina Petrillo, Lavinia Saldamarco,

Cardiovascular Research · 2012 · 50 citations · 18 references

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Abstract

Enhanced SOCS1 myocardial signalling is associated with accelerated transition from hypertrophy to failure in an established model of pressure overload. SOCS1 may represent an attractive target for the prevention of heart failure progression.

References

18

A family of cytokine-inducible inhibitors of signalling

Robyn Starr, Tracy A. Willson, Elizabeth M. Viney et al. · Nature · 1997 · 2.1K citations · Full text

, , +6

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Hideo Yasukawa, Masanobu Ohishi, Hiroyuki Mori et al. · Nature Immunology · 2003 · 776 citations

, , +11

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

Hisao Hirota, Ju Chen, Ulrich A. K. Betz et al. · Cell · 1999 · 661 citations · Full text

, , +10

Modulation of ventricular function through gene transfer <i>in vivo</i>

Roger J. Hajjar, Ulrich Schmidt, Takashi Matsui et al. · Proceedings of the National Academy of Sciences · 1998 · 294 citations · Full text

, , +16

Differential Cardiac Effects of Growth Hormone and Insulin-like Growth Factor1 in the Rat

Antonio Cittadini, Hinrik Strömer, Sarah E. Katz et al. · Circulation · 1996 · 277 citations